Blar i NTNU Open på forfatter "Walker, Venexia M."

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    • How to estimate heritability: a guide for genetic epidemiologists 

      Barry, Ciarra-Jane S; Walker, Venexia M.; Cheesman, Rosa Catherine Gillespie; Smith, George Davey; Morris, Tim T; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Background Traditionally, heritability has been estimated using family-based methods such as twin studies. Advancements in molecular genomics have facilitated the development of methods that use large samples of (unrelated ...

    • Little genomic support for Cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriers 

      Anderson, Emma L.; Williams, Dylan M.; Walker, Venexia M.; Davies, Neil Martin (Peer reviewed; Journal article, 2022)
      Therapeutic targets for halting the progression of Alzheimer’s disease pathology are lacking. Recent evidence suggests that APOE4, but not APOE3, activates the Cyclophilin-A matrix metalloproteinase-9 (CypA-MMP9) pathway, ...

    • Mendelian randomization for studying the effects of perturbing drug targets 

      Gill, Dipender; Georgakis, Marios K.; Walker, Venexia M.; Schmidt, Amand F.; Gkatzionis, Apostolos; Freitag, Daniel F.; Finan, Chris; Hingorani, Aroon D.; Howson, Joanna M.M.; Burgess, Stephen; Swerdlow, Daniel I.; Davey Smith, George; Holmes, Michael V.; Dichgans, Martin; Scott, Robert A.; Zheng, Jie; Psaty, Bruce M.; Davies, Neil Martin (Peer reviewed; Journal article, 2021)
      Drugs whose targets have genetic evidence to support efficacy and safety are more likely to be approved after clinical development. In this paper, we provide an overview of how natural sequence variation in the genes that ...

    • Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes 

      Walker, Venexia M.; Vujkovic, Marijana; Carter, Alice R.; Davies, Neil Martin; Udler, Miriam S.; Levin, Michael G.; Davey Smith, George; Voight, Benjamin F.; Gaunt, Tom R.; Damrauer, Scott M. (Peer reviewed; Journal article, 2022)
      Aims/hypothesis Type 2 diabetes and atherosclerotic CVD share many risk factors. This study aimed to systematically assess a broad range of continuous traits to separate their direct effects on coronary and peripheral ...

    • Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease 

      Zheng, Jie; Zhang, Yuemiao; Rasheed, Humaira; Walker, Venexia M.; Sugawara, Yuka; Li, Jiachen; Leng, Yue; Elsworth, Benjamin; Wootton, Robyn E.; Fang, Si; Yang, Qian; Burgess, Stephen; Haycock, Philip C.; Borges, Maria Carolina; Carnegie, Rebecca; Cho, Yoonsu; Howell, Amy; Robinson, Jamie; Thomas, Laurent; Brumpton, Ben Michael; Hveem, Kristian; Hallan, Stein; Franceschini, Nora; Morris, Andrew P.; Köttgen, Anna; Pattaro, Cristian; Wuttke, Matthias; Yamamoto, Masayuki; Kashihara, Naoki; Akiyama, Masato; Kanai, Masahiro; Matsuda, Koichi; Kamatani, Yoichiro; Okada, Yukinori; Walters, Robin; Millwood, Iona Y.; Chen, Zhengming; Smith, George Davey; Barbour, Sean; Yu, Canqing; Åsvold, Bjørn Olav; Zhang, Hong; Gaunt, Tom R. (Peer reviewed; Journal article, 2021)
      Background: This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD in European and East Asian ancestries using Mendelian randomization. ...